1dc0

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Image:1dc0.gif

1dc0, resolution 1.3Å

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CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG

Overview

The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.

About this Structure

1DC0 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897

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