This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Lactoferrin
From Proteopedia
Lactoferrin (LTF) is found in secretory fluids. It is a component of the immune system and has antimicrobial activity. LTF interacts with DNA, RNA, polysaccharides and heparin. LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. For detailed discussion of human lactoferrin see Human lactoferrin.
Contents |
3D Structures of lactoferrin
Updated on 11-June-2014
Apo lactoferrin
1i6b, 1b7u – hoLTF – horse
1dtz – cLTF - camel
1cb6, 1lfg, 1lfh – hLTF - human
1u62, 1xv4, 1xv7, 1z6v, 1z6w - hLTF peptide – NMR
1lfc – bLTF residues 17-41 – bovine – NMR
1y58, 1y5c - bLTF residues 4-14 – NMR
4oqo – bLTF C lobe
Lactoferrin
1blf – bLTF + 2Fe
1sdx - bLTF C lobe + 3Zn
1nkx, 3u8q - bLTF C lobe + 2Zn + Fe
1b1x, 1f9b – hoLTF + 2Fe
1qjm – hoLTF + 2Sm
1ce2, 1biy – buLTF + 2Fe - buffalo
1i6q – cLTF + 2Fe
2bjj, 1sqy, 1n76– hLTF + 2Fe
1b0l - hLTF (mutant) + 2Fe
1fck – hLTF + 2Ce
1lfi - hLTF + 2Cu
1lct - hLTF N lobe + 2Fe
1h43, 1h44, 1h45, 1l5t, 1eh3, 1vfd, 1vfe, 1hse, 1dsn - hLTF N lobe (mutant) + 2Fe
1jw1 – LTF + 2Fe – goat
Lactoferrin binary complex
3sdf – bLTF C lobe + lipoteichoic acid + 2Zn + Fe
4n6p - bLTF C lobe + meclofenamic acid + 2Zn + Fe
4ned - bLTF C lobe + fenoprofen + 2Zn + Fe
3rgy - bLTF C lobe + lipopolysaccharide + Zn + Fe
3kj7, 3k0v, 2q8j, 2o51, 2nwj, 2dxy, 2dwj, 2dsf, 2ds9, 2hca, 2dqv, 2dp8, 2g93, 2ays, 2alu, 2dwi, 2dyx, 2o1l, 2p1s - bLTF C lobe + polysaccharide + 2Zn + Fe
2o1l - bLTF C lobe + polysaccharide + Zn + Fe
2fa7, 2b65 - bLTF C lobe + polysaccharide + 3Zn + Fe
2dvc, 2dwa, 2dwh, 2e0s, 2e1s, 2h4i, 2px1 - bLTF C lobe + saccharide + 2Zn + Fe
2dxr - bLTF C lobe + sorbitol+ 2Zn + Fe
3iaz, 3ib0, 3ib1 - bLTF C lobe (mutant) + NSAID + 2Zn + Fe
3e9x, 2qje, 2zmb, 3crb, 2nuv, 4fim, 4fjp, 4for, 4g2z, 4g77, 4g8h, 4grk, 3taj - bLTF C lobe + NSAID + 2Zn + Fe
3o97, 3mjn, 3cfl, 2ocu, 3tod, 3tus – bLTF C lobe + inhibitor + 2Zn + Fe
3ib2 - bLTF C lobe (mutant) + inhibitor + 2Zn + Fe
2doj - bLTF C lobe + adenosine + 2Zn + Fe
3ugw - bLTF C lobe + deoxycytidine + 2Zn + Fe
3ci8 - bLTF C lobe + niacin + 2Zn + Fe
2r9j - bLTF C lobe + nicotinamide + 2Zn + Fe
2r71 - bLTF C lobe + inositol + 2Zn + Fe
3uk4 - bLTF C lobe + pentatriol + 2Zn + Fe
3usd - bLTF C lobe + pyridine derivative + 2Zn + Fe
3ttr - bLTF C lobe + anasthetic + 2Zn + Fe
3vdf - bLTF C lobe + diaminopimelic acid + 2Zn + Fe
4dxu - bLTF C lobe + caproic acid + 2Zn + Fe
3v5a - bLTF C lobe + γ-amino butyric acid + 2Zn + Fe
3u72, 4dig - bLTF C lobe + polypeptide + 2Zn + Fe
3ptl – bLTF peptide + proteinase K
1bjr - buLTF peptide + proteinase K
1b7z - hoLTF + 2Fe + oxalate
3cr9 – hoLTF + inhibitor + 2Fe
2j4u – cLTF N terminal + OMPC
1bka - hLTF + 2Fe + oxalate
1lcf - hLTF + 2Cu + oxalate
2pms – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe
