Proliferating Cell Nuclear Antigen
From Proteopedia
Proliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, i.e. the crystal structure of Proliferating Cell Nuclear Antigen from Archaeglobus fulgidus (1rwz).
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3D Structures of Proliferating Cell Nuclear Antigen
Updated on 13-April-2014
Unliganded PCNA
1rwz – AfPCNA - Archaeglobus fulgidus
3lx1 - TkPCNA1 - Thermococcus kodakarensis
3lx2 - TkPCNA2
3lox, 1plq, 1plr – yPCNA - yeast
3f1x, 3gpm, 3gpn, 3f1w, 4l60 - yPCNA (mutant)
3l0x - yPCNA N fragment + C fragment
3pge - yPCNA N fragment + SUMO-C fragment
1vym, 1w60, 3vkx – hPCNA - human
2io4 – SsPCNA B (mutant) + PCNA C - Sulfolobus solfataricus
2hii, 2hik, 2ixi, 2ix2 - SsPCNA A + PCNA B + PCNA C
2nti - SsPCNA A + PCNA B (mutant) + PCNA C
2ijx - SsPCNA A
1iz4, 1iz5, 1ge8 – PfPCNA (mutant) - Pyrococcus furiosus
3hi8, 3ifv - PCNA - Haloferax volcanii
3aix, 3aiz - StPCNA B + PCNA C – Sulfolobus tokodaii
1ud9 - StPCNA
3p91 – PCNA – Entamoeba histoytiica
4hk1 – PCNA – Drosophila melanogaster
PCNA + Dpo
2zvk – hPCNA + hDpo ε
2zvl – hPCNA + hDpo κ
2zvm – hPCNA + hDpo τ
3fds – SsPCNA B + PCNA C + SsDpo IV
3a2f - PfPCNA + Dpo
PCNA complexes
1vyj, 1u76, 1u7b – hPCNA + peptide
3wgw – hPCNA + inhibitor
1axc - hPCNA + P21/WAF1 C-terminat
1ul1 - hPCNA + Flap exonuclease-1
3p87 - hPCNA + RNase H2 subunit B (mutant)
3tbl - hPCNA + ubiquitin
3p83 - AfPCNA + RNase H2
1rxm – AfPCNA + Flap exonuclease-1 peptide
1rxz - AfPCNA + Flap structure-specific endonuclease
3l0w, 3l10 - yPCNA + monoubiquinated PCNA
1sxj – yPCNA + replication factor C
2od8 - yPCNA + DNA ligase fragment
3k4x - yPCNA + DNA
3v60, 3v61 – yPCNA (mutant) + ubiquitin-like protein SMT3
3v62 – yPCNA (mutant) + ubiquitin-like protein SMT3 + ATP-dependent DNA helicase SRS2
2izo - SsPCNA B + PCNA C + Flap structure-specific endonuclease
1isq - PfPCNA (mutant) + replication factor C large subunit
2zvw, 2zvv - PCNA + cyclin-dependent kinase inhibitor 1 - Arabidopsis thaliana
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Lukáš Cakl, Joel L. Sussman
