Proteinase
From Proteopedia
Proteinase (PRO) are enzymes which hydrolyze peptide bonds. They are classified by the amino acid site of their cleavage or by the pH at which they are active. PRO B is a serine protease. For more details on PRO B see Streptomyces griseus proteinase B. PRO A is a carboxylproteinase. PRO K is a serine protease which cleaves proteins preferentially after hydrophobic residues. Calcium ions contribute to the stability of the enzyme. PRO K is active over a wide pH range and is used in molecular biology to inactivate nucleases from preparations of DNA or RNA. PRO K is used in the partial proteolysis of lactoferrin into its N- and C-lobe. The two lobes of lactoferrin have different antimicrobial and antifungal properties. PRO K can digest hair (keratin).
3D structures of proteinaseUpdated on 20-August-2014 PRO A2sga – SgPRO – Streptomyces griseus PRO B3sgb – SgPRO + turkey ovomucoid inhibitor PRO K2prk, 1cnm, 1egq, 2id8, 2g4v, 2v8b, 3gt3, 3gt4, 3d9q, 3ddz, 3de0 , 3de1, 3de2, 3de3, 3de4, 3de5, 3de6, 3de7, 3dvq, 3dvr, 3dvs, 3dw1, 3dw3, 3dwe, 3i2y, 3i30, 3i37, 3i34, 3l1k, 3aj8, 3aj9, 3q40, 3q5g, 3qmp, 4b5l, 4fon – EaPRO + Ca – Engyodontium album PRO K complex with peptide 3prk, 1p7v, 1p7w – EaPRO + Ca + peptide inhibitor 1bjr, 2dqk, 2duj – EaPRO + Ca + lactoferrin peptide PRO K complex with small molecule 2pwb – EaPRO + Ca + coumarin 2pyz – EaPRO + Ca + auramine PRO 3C1qa7 – PRO – Hepatitis virus H2-PRO1wni – PRO – Trimeresurus flavoviridis Aspartic PRO2asi – PRO – Rhizomucor miehei Cysteine PRO2hrv – PRO 2A – human rhinovirus Serine PRO1s2n, 1sh7 – PRO – Vibrio
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References
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Alexander Berchansky, Karsten Theis
