Ribosomal protein S6 kinase

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Template:STRUCTURE 2z7q

Ribosomal protein S6 kinase (RPS6K) regulates RPS6. The images at the left and at the right correspond to one representative RPS6K, i.e. the crystal structure of human Ribosomal protein S6 kinase (2z7q).

3D Structures of Ribosomal protein S6 kinase

Updated on 23-April-2014

2wnt – hRPS6K C-terminal residues 414-738 – human

RPS6K α

2z7q - hRPS6K α−1 N-terminal kinase domain
3rny - hRPS6K α−1 C-terminal kinase domain
2qr7, 2qr8 - mRPS6K α−3 C-terminal kinase domain (mutant) - mouse
3g51 - mRPS6K α−3 N-terminal kinase domain
1vzo - hRPS6K α−5 N-terminal kinase domain (mutant)
3kn6 - hRPS6K α−5 C-terminal kinase domain

RPS6K α complex

2z7s, 2z7r - hRPS6K α−1 N-terminal kinase domain+inhibitor
3ubd - hRPS6K α−3 N-terminal kinase domain + flavonol glycoside
4gue - mRPS6K α−3 N-terminal kinase domain + flavonol glycoside
4el9 - mRPS6K α−3 N-terminal kinase domain + inhibitor
4nus, 4nw5, 4nw6 - hRPS6K α−3 N-terminal kinase domain + inhibitor
4d9t, 4d9u, 4jg6, 4jg7, 4jg8 - hRPS6K α−3 C-terminal kinase domain + inhibitor
3kn5 - hRPS6K α−5 C-terminal kinase domain+AMPPNP

RPS6K β

3a60, 3a61, 3a62, 4l3j, 4l3l - hRPS6K β−1 kinase domain
4l42, 4l43, 4l44, 4l45, 4l46 - hRPS6K β−1 kinase domain + pyrimidine derivative