Function
Beta-phosphoglucomutase (BPGM) catalyzes the conversion of β-D-glucose 1-phosphate to β-D-glucose 6-phosphate. Mg+2 ion is the cofactor of the reaction and BPGM activation is achieved by Asp8 phosphorylation (D8P). α-D-galactose-1-phosphate is an inhibitor of BPGM. BPGM participates in sugar and starch metabolism.
Disease
Relevance
Structural highlights
3D Structures of β-phosphoglucomutase
Updated on 24-July-2014
3nas – BPGM – Bacillus subtilis
4g9b – BPGM + Mg – Escherichia coli
1zol, 2whe – LlBPGM + Mg – Lactococcus lactis
3fm9 – LlBPGM (mutant) + Mg
2wfa – LlBPGM + BeF3 + Mg
1lvh – LlBPGM + D8P + Mg
Beta-phosphoglucomutase complex with glucophosphate derivatives
1o03, 1o08 – LlBPGM + α-D-glucose 1,6-bisphosphate + Mg
1z4n, 1z4o – LlBPGM + α-D-galactose-1-phosphate + Mg
2wf5 – LlBPGM + β-D-glucose-6-phosphate + MgF3 + Mg
3zi4 – LlBPGM + β-D-glucose-6-phosphate + ScF4 + Mg
2wf6 – LlBPGM + β-D-glucose-6-phosphate + AlF4 + Mg
2wf7 – LlBPGM + dideoxy-phosphono-β-D-gluco-heptopyranose + AlF4 + Mg
4c4r, 4c4s – LlBPGM + β-phosphonomethylene-D-glucopyranose derivative + MgF3 + Mg
4c4t – LlBPGM + β-phosphonomethylene-D-glucopyranose derivative + AlF4 + Mg
2wf8 – LlBPGM + β-D-glucose-6-phosphate + α-D-glucose-1-phosphate + BeF3 + Mg
2wf9 – LlBPGM + β-D-glucose-6-phosphate + α-D-glucose-6-phosphate + BeF3 + Mg
References
