4hqj

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4hqj

Contents 1 Crystal structure of Na+,K+-ATPase in the Na+-bound state 2 Function 3 About this Structure 4 Reference

Crystal structure of Na+,K+-ATPase in the Na+-bound state

Template:ABSTRACT PUBMED 24051246

Function

[AT1A1_PIG] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [AT1B1_PIG] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

About this Structure

4hqj is a 6 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

• Nyblom M, Poulsen H, Gourdon P, Reinhard L, Andersson M, Lindahl E, Fedosova N, Nissen P. Crystal Structure of Na+, K+-ATPase in the Na+-Bound State. Science. 2013 Sep 19. PMID:24051246 doi:10.1126/science.1243352