Proto-oncogene serine/threonine-protein kinase

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Proto-oncogene serine/threonine-protein kinase (Pim1) is implicated with a variety of cancers. Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signaling pathways. Pim1 phosphorylates and inhibits proapoptotic proteins. Pim1 is phosphorylated on serine 261 (PSer). The consensus peptide (pimtide) ARKRRRHPSGPPTA binds strongly to Pim1.

1 3D Structures of pim-1

3D Structures of pim-1

Updated on 20-August-2014

1xqz, 1ywv – hPim1 – human
1yxs – hPim1 (mutant)
1xr1, 1yxt – hPim1 + AMPPNP
1yxu – hPim1 + AMP
1yxv, 3uix – hPim1 + quinoline derivative
1yxx – hPim1 + indole derivative
3a99 – hPim1 + phosphoaminophosphonic acid adenylate
2bzj, 2bzh, 2bzi, 2oi4, 3bwf – hPim1 (mutant) + organometallic ligand
1xws, 2o3p, 2o63, 2o64, 2o65, 3jxw, 3jy0, 3jya, 3r00, 3r01, 3r02, 3r04, 3vbq, 3vbt, 3vbv, 3vbw, 3vbx, 3vby, 3vc4, 4dtk, 3umx, 4enx, 4eny, 3umw, 4as0, 4alu, 4alv, 4alw, 4bzn, 4bzo, 4ll5, 4lm5 – hPim1 + inhibitor
2j2i – hPim1 (mutant)+ inhibitor

Pim1 complex with consensus peptide

2c3i, 4gw8 – hPim1 (mutant) + inhibitor + consensus peptide
2bzk – hPim1 (mutant)+ AMPPNP + consensus peptide
2bil, 3cxw, 3cy2, 3cy3, 3jpv, 3qf9 – hPim1 + inhibitor + consensus peptide
3ma3 – hPim1 + inhibitor + PSer + consensus peptide

Pim1 containing phosphorylated Ser 261

1yhs – hPim1 + PSer + staurosporine
1yi3, 2bik, 2obj, 3bgp, 3bgq, 3bgz, 3dcv, 3f2a, 2xix, 2xiy, 2xiz, 2xj0, 2xj1, 2xj2, 3t9i, 4a7c – hPim1 + PSer + inhibitor
1yi4 – hPim1 + PSer + adenosine