4g1p

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Template:STRUCTURE 4g1p

Contents 1 Structural and Mechanistic Basis of Substrate Recognition by Novel Di-peptidase Dug1p From Saccharomyces cerevisiae 2 Function 3 About this Structure 4 Reference

Structural and Mechanistic Basis of Substrate Recognition by Novel Di-peptidase Dug1p From Saccharomyces cerevisiae

Function

[DUG1_YEAST] Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides.^{[1] [2]}

About this Structure

4g1p is a 1 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

1. ↑ Ganguli D, Kumar C, Bachhawat AK. The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae. Genetics. 2007 Mar;175(3):1137-51. Epub 2006 Dec 18. PMID:17179087 doi:10.1534/genetics.106.066944
2. ↑ Kaur H, Kumar C, Junot C, Toledano MB, Bachhawat AK. Dug1p Is a Cys-Gly peptidase of the gamma-glutamyl cycle of Saccharomyces cerevisiae and represents a novel family of Cys-Gly peptidases. J Biol Chem. 2009 May 22;284(21):14493-502. doi: 10.1074/jbc.M808952200. Epub, 2009 Apr 3. PMID:19346245 doi:10.1074/jbc.M808952200