1tr6

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Template:STRUCTURE 1tr6

Contents 1 NMR solution structure of omega-conotoxin [K10]GVIA, a cyclic cysteine knot peptide 2 Function 3 About this Structure 4 Reference

NMR solution structure of omega-conotoxin [K10]GVIA, a cyclic cysteine knot peptide

Template:ABSTRACT PUBMED 15166237

Function

[CXO6_CONGE] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).

About this Structure

1tr6 is a 1 chain structure with sequence from Conus geographus. Full experimental information is available from OCA.

Reference

• Mould J, Yasuda T, Schroeder CI, Beedle AM, Doering CJ, Zamponi GW, Adams DJ, Lewis RJ. The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J Biol Chem. 2004 Aug 13;279(33):34705-14. Epub 2004 May 27. PMID:15166237 doi:10.1074/jbc.M310848200