1hvy

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spinqualitylabelsall models PDB ID 1hvy Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1hvy, resolution 1.90Å ()
Ligands:	, ,
Non-Standard Residues:
Activity:	Thymidylate synthase, with EC number 2.1.1.45
Structural annotation: Resources: CATH : 1Hvya00, 1Hvyb00, 1Hvyc00, 1Hvyd00 InterPro : Ipr020940, Ipr000398, Ipr023451 Pfam : PF00303 SCOP : d1hvya_, d1hvyb_, d1hvyc_, d1hvyd_
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation 2 About this Structure 3 See Also 4 Reference

Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation

Template:ABSTRACT PUBMED 11329255

About this Structure

1hvy is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Thymidylate synthase

Reference

• Phan J, Koli S, Minor W, Dunlap RB, Berger SH, Lebioda L. Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug. Biochemistry. 2001 Feb 20;40(7):1897-902. PMID:11329255