1gen

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Image:1gen.gif

1gen, resolution 2.15Å

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C-TERMINAL DOMAIN OF GELATINASE A

Contents

Overview

The crystal structure of the haemopexin-like C-terminal domain of gelatinase A reveals that it is a four-bladed beta-propeller protein. The four blades are arranged around a channel-like opening in which Ca2+ and a Na-Cl+ ion pair are bound.

Disease

Known diseases associated with this structure: Osteolysis, idiopathic, Saudi type OMIM:[120360], Winchester syndrome OMIM:[120360]

About this Structure

1GEN is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Active as Gelatinase A, with EC number 3.4.24.24 Full crystallographic information is available from OCA.

Reference

Crystal structure of the haemopexin-like C-terminal domain of gelatinase A., Libson AM, Gittis AG, Collier IE, Marmer BL, Goldberg GI, Lattman EE, Nat Struct Biol. 1995 Nov;2(11):938-42. PMID:7583664

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