1g1r

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spinqualitylabelsall models PDB ID 1g1r Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1g1r, resolution 3.40Å ()
Ligands:	, , , ,
Non-Standard Residues:
Related:	1g1q, 1g1s, 1g1t
Structural annotation: Resources: CATH : 1G1Ra02, 1G1Ra01, 1G1Rb01, 1G1Rb02, 1G1Rc01, 1G1Rc02, 1G1Rd02, 1G1Rd01 InterPro : Ipr006210, Ipr002396, Ipr013032, Ipr000436, Ipr006209, Ipr001304, Ipr000742 Pfam : PF00008, PF00059 SCOP : d1g1ra1, d1g1ra2, d1g1rb2, d1g1rb1, d1g1rc1, d1g1rc2, d1g1rd2, d1g1rd1 UniProt : P16109
Functional annotation: Cellular component: integral to membrane membrane plasma membrane membrane fraction integral to plasma membrane platelet alpha granule membrane soluble fraction Biological process: cell adhesion Molecular function: sugar binding protein binding carbohydrate binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Crystal structure of P-selectin lectin/EGF domains complexed with SLeX 2 Disease 3 Function 4 About this Structure 5 Reference

Crystal structure of P-selectin lectin/EGF domains complexed with SLeX

Template:ABSTRACT PUBMED 11081633

Disease

[LYAM3_HUMAN] Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.^[1]

Function

[LYAM3_HUMAN] Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.^[2]

About this Structure

1g1r is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Somers WS, Tang J, Shaw GD, Camphausen RT. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell. 2000 Oct 27;103(3):467-79. PMID:11081633

1. ↑ Zee RY, Cook NR, Cheng S, Reynolds R, Erlich HA, Lindpaintner K, Ridker PM. Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis. Hum Mol Genet. 2004 Feb 15;13(4):389-96. Epub 2003 Dec 17. PMID:14681304 doi:10.1093/hmg/ddh039
2. ↑ Pouyani T, Seed B. PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus. Cell. 1995 Oct 20;83(2):333-43. PMID:7585950