1kcm

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Template:STRUCTURE 1kcm

Contents

Crystal Structure of Mouse PITP Alpha Void of Bound Phospholipid at 2.0 Angstroms Resolution

Template:ABSTRACT PUBMED 11980708

Disease

[PIPNA_MOUSE] Note=Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels.

Function

[PIPNA_MOUSE] Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

About this Structure

1kcm is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Schouten A, Agianian B, Westerman J, Kroon J, Wirtz KW, Gros P. Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association. EMBO J. 2002 May 1;21(9):2117-21. PMID:11980708 doi:http://dx.doi.org/10.1093/emboj/21.9.2117

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