1qtu

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 1qtu

Contents 1 SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1 2 Disease 3 Function 4 About this Structure 5 Reference

SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1

Template:ABSTRACT PUBMED 10959629

Disease

[MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.

Function

[MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.^[1]

About this Structure

1qtu is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

• Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C. Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data. J Biomol NMR. 2000 Jul;17(3):215-30. PMID:10959629

1. ↑ Laine J, Kunstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell. 2000 Aug;6(2):395-407. PMID:10983986