1h9e

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Template:STRUCTURE 1h9e

Contents

LEM-LIKE DOMAIN OF HUMAN INNER NUCLEAR MEMBRANE PROTEIN LAP2

Template:ABSTRACT PUBMED 11435115

Function

[LAP2B_HUMAN] May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95. TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

About this Structure

1h9e is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Laguri C, Gilquin B, Wolff N, Romi-Lebrun R, Courchay K, Callebaut I, Worman HJ, Zinn-Justin S. Structural characterization of the LEM motif common to three human inner nuclear membrane proteins. Structure. 2001 Jun;9(6):503-11. PMID:11435115

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