1cf1

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Template:STRUCTURE 1cf1

Contents

ARRESTIN FROM BOVINE ROD OUTER SEGMENTS

Template:ABSTRACT PUBMED 10219246

Disease

[ARRS_BOVIN] Note=S-antigen induces autoimmune uveitis.

Function

[ARRS_BOVIN] Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Isoform B plays a role in the phototransduction cascade.

About this Structure

1cf1 is a 4 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Hirsch JA, Schubert C, Gurevich VV, Sigler PB. The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation. Cell. 1999 Apr 16;97(2):257-69. PMID:10219246

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