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1qtt

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Template:STRUCTURE 1qtt

Contents

SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1

Template:ABSTRACT PUBMED 10959629

Disease

[MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.

Function

[MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.[1]

About this Structure

1qtt is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C. Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data. J Biomol NMR. 2000 Jul;17(3):215-30. PMID:10959629
  1. ↑ Laine J, Kunstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell. 2000 Aug;6(2):395-407. PMID:10983986

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