1k4w

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Template:STRUCTURE 1k4w

Contents 1 X-ray structure of the orphan nuclear receptor ROR beta ligand-binding domain in the active conformation 2 Function 3 About this Structure 4 Reference

X-ray structure of the orphan nuclear receptor ROR beta ligand-binding domain in the active conformation

Template:ABSTRACT PUBMED 11689423

Function

[RORB_RAT] Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter.

About this Structure

1k4w is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

• Stehlin C, Wurtz JM, Steinmetz A, Greiner E, Schule R, Moras D, Renaud JP. X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. EMBO J. 2001 Nov 1;20(21):5822-31. PMID:11689423 doi:10.1093/emboj/20.21.5822