1brq

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Template:STRUCTURE 1brq

Contents

CRYSTAL STRUCTURE OF THE TRIGONAL FORM OF HUMAN PLASMA RETINOL-BINDING PROTEIN AT 2.5 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8464067

Disease

[RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.

Function

[RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

About this Structure

1brq is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zanotti G, Ottonello S, Berni R, Monaco HL. Crystal structure of the trigonal form of human plasma retinol-binding protein at 2.5 A resolution. J Mol Biol. 1993 Mar 20;230(2):613-24. PMID:8464067 doi:http://dx.doi.org/10.1006/jmbi.1993.1173

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