1pr9
From Proteopedia
Contents |
Human L-Xylulose Reductase Holoenzyme
Template:ABSTRACT PUBMED 15103634
Disease
[DCXR_HUMAN] Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
Function
[DCXR_HUMAN] Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
About this Structure
1pr9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- El-Kabbani O, Ishikura S, Darmanin C, Carbone V, Chung RP, Usami N, Hara A. Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis. Proteins. 2004 May 15;55(3):724-32. PMID:15103634 doi:10.1002/prot.20047
- El-Kabbani O, Chung RP, Ishikura S, Usami N, Nakagawa J, Hara A. Crystallization and preliminary crystallographic analysis of human L-xylulose reductase. Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1379-80. Epub 2002, Jul 20. PMID:12136162
