2dqt

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Image:2dqt.png

Template:STRUCTURE 2dqt

High resolution crystal structure of the complex of the hydrolytic antibody Fab 6D9 and a transition-state analog

Template:ABSTRACT PUBMED 17428500

About this Structure

2dqt is a 2 chain structure with sequence from Mus musculus. This structure supersedes the now removed PDB entry 1hyx. Full crystallographic information is available from OCA.

Reference

  • Oda M, Ito N, Tsumuraya T, Suzuki K, Sakakura M, Fujii I. Thermodynamic and structural basis for transition-state stabilization in antibody-catalyzed hydrolysis. J Mol Biol. 2007 May 25;369(1):198-209. Epub 2007 Mar 15. PMID:17428500 doi:10.1016/j.jmb.2007.03.023
  • Miyashita H, Hara T, Tanimura R, Fukuyama S, Cagnon C, Kohara A, Fujii I. Site-directed mutagenesis of active site contact residues in a hydrolytic abzyme: evidence for an essential histidine involved in transition state stabilization. J Mol Biol. 1997 Apr 18;267(5):1247-57. PMID:9150409 doi:10.1006/jmbi.1997.0938
  • Miyashita H, Hara T, Tamimura R, Tanaka F, Kikuchi M, Fujii I. A common ancestry for multiple catalytic antibodies generated against a single transition-state analog. Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10757. PMID:7938025

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