2a41

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Template:STRUCTURE 2a41

Contents

Ternary complex of the WH2 Domain of WIP with Actin-DNAse I

Template:ABSTRACT PUBMED 16275905

Function

[ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [DNAS1_BOVIN] Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity).

About this Structure

2a41 is a 3 chain structure with sequence from Bos taurus and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

See Also

Reference

  • Chereau D, Kerff F, Graceffa P, Grabarek Z, Langsetmo K, Dominguez R. Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16644-9. Epub 2005 Nov 7. PMID:16275905

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