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2bb5

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Template:STRUCTURE 2bb5

Contents

Structure of Human Transcobalamin in complex with Cobalamin

Template:ABSTRACT PUBMED 16537422

Disease

[TCO2_HUMAN] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.

Function

[TCO2_HUMAN] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

About this Structure

2bb5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wuerges J, Garau G, Geremia S, Fedosov SN, Petersen TE, Randaccio L. Structural basis for mammalian vitamin B12 transport by transcobalamin. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4386-91. Epub 2006 Mar 14. PMID:16537422

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