2a07

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spinqualitylabelsall models PDB ID 2a07 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2a07, resolution 1.90Å ()
Ligands:
Gene:	FOXP2, CAGH44, TNRC10 (Homo sapiens)
Structural annotation: Resources: InterPro : Ipr001766, Ipr015880, Ipr011991, Ipr007087 Pfam : PF00250 UniProt : O15409
Functional annotation: Cellular component: intracellular nucleus Biological process: transcription putamen development regulation of transcription, DNA-dependent caudate nucleus development Molecular function: sequence-specific DNA binding metal ion binding zinc ion binding protein homodimerization activity transcription factor activity nucleic acid binding DNA binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Crystal Structure of Foxp2 bound Specifically to DNA. 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Crystal Structure of Foxp2 bound Specifically to DNA.

Template:ABSTRACT PUBMED 16407075

Disease

[FOXP2_HUMAN] Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1) [MIM:602081]; also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation. They also show deficits in several facets of language processing (such as the ability to break up words into their constituent phonemes) and grammatical skills.^[1] Note=A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).

Function

[FOXP2_HUMAN] Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language.

About this Structure

2a07 is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• FOXP2
• Forkhead box protein
• Foxp2 bound specifically to DNA

Reference

• Stroud JC, Wu Y, Bates DL, Han A, Nowick K, Paabo S, Tong H, Chen L. Structure of the forkhead domain of FOXP2 bound to DNA. Structure. 2006 Jan;14(1):159-66. PMID:16407075 doi:10.1016/j.str.2005.10.005

1. ↑ Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature. 2001 Oct 4;413(6855):519-23. PMID:11586359 doi:10.1038/35097076