2exg

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Template:STRUCTURE 2exg

Contents

Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain

Disease

[AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.

Function

[AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.

About this Structure

2exg is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Joshi M, Vargas C, Boisguerin P, Diehl A, Krause G, Schmieder P, Moelling K, Hagen V, Schade M, Oschkinat H. Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3790-5. PMID:16671149 doi:10.1002/anie.200503965

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OCA

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