1jvn

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Template:STRUCTURE 1jvn

Contents

CRYSTAL STRUCTURE OF IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE: A TUNNEL THROUGH A (BETA/ALPHA)8 BARREL JOINS TWO ACTIVE SITES

Template:ABSTRACT PUBMED 11591353

Function

[HIS5_YEAST] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutamine amidotransferase domain provides the ammonia necessary to the cyclase domain to produce IGP and AICAR from PRFAR.

About this Structure

1jvn is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Chaudhuri BN, Lange SC, Myers RS, Chittur SV, Davisson VJ, Smith JL. Crystal structure of imidazole glycerol phosphate synthase: a tunnel through a (beta/alpha)8 barrel joins two active sites. Structure. 2001 Oct;9(10):987-97. PMID:11591353
  • Korolev S, Skarina T, Evdokimova E, Beasley S, Edwards A, Joachimiak A, Savchenko A. Crystal structure of glutamine amidotransferase from Thermotoga maritima. Proteins. 2002 Nov 15;49(3):420-2. PMID:12360532 doi:10.1002/prot.10161

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