1cwo

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Template:STRUCTURE 1cwo

Contents

HUMAN CYCLOPHILIN A COMPLEXED WITH THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN

Template:ABSTRACT PUBMED 9769217

Function

[PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

About this Structure

1cwo is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mikol V, Taylor P, Kallen J, Walkinshaw MD. Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A. J Mol Biol. 1998 Oct 23;283(2):451-61. PMID:9769217 doi:10.1006/jmbi.1998.2109

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