1e98

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Template:STRUCTURE 1e98

Contents 1 Wild type human thymidylate kinase complexed with AZTMP and ADP 2 Function 3 About this Structure 4 See Also 5 Reference

Wild type human thymidylate kinase complexed with AZTMP and ADP

Template:ABSTRACT PUBMED 11071809

Function

[KTHY_HUMAN] Catalyzes the conversion of dTMP to dTDP.

About this Structure

1e98 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Thymidylate kinase

Reference

• Ostermann N, Lavie A, Padiyar S, Brundiers R, Veit T, Reinstein J, Goody RS, Konrad M, Schlichting I. Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. J Mol Biol. 2000 Nov 17;304(1):43-53. PMID:11071809 doi:10.1006/jmbi.2000.4175
• Ostermann N, Schlichting I, Brundiers R, Konrad M, Reinstein J, Veit T, Goody RS, Lavie A. Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate. Structure. 2000 Jun 15;8(6):629-42. PMID:10873853