1syl

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Template:STRUCTURE 1syl

Contents

Crystal structure of inactive mutant dUTPase complexed with substrate dUTP

Template:ABSTRACT PUBMED 15208312

Function

[DUT_ECOLI] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]

About this Structure

1syl is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

See Also

Reference

  • Barabas O, Pongracz V, Kovari J, Wilmanns M, Vertessy BG. Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J Biol Chem. 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PMID:15208312 doi:10.1074/jbc.M406135200

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