2jyb

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Template:STRUCTURE 2jyb

Contents

binary hvDHFR1:folate complex

Template:ABSTRACT PUBMED 18825778

Function

[DYR_HALVD] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).

About this Structure

2jyb is a 1 chain structure with sequence from Haloferax volcanii. Full experimental information is available from OCA.

Reference

  • Boroujerdi AF, Young JK. NMR-derived folate-bound structure of dihydrofolate reductase 1 from the halophile Haloferax volcanii. Biopolymers. 2009 Feb;91(2):140-4. doi: 10.1002/bip.21096. PMID:18825778 doi:10.1002/bip.21096

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OCA

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