2wj8

From Proteopedia

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Template:STRUCTURE 2wj8

Contents 1 Respiratory Syncitial Virus RiboNucleoProtein 2 Function 3 About this Structure 4 See Also 5 Reference

Respiratory Syncitial Virus RiboNucleoProtein

Template:ABSTRACT PUBMED 19965480

Function

[NCAP_HRSVA] Encapsidates the genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases.^[1]

About this Structure

2wj8 is a 40 chain structure with sequence from Escherichia coli and Human respiratory syncytial virus a strain long. Full crystallographic information is available from OCA.

See Also

• Nucleoprotein

Reference

• Tawar RG, Duquerroy S, Vonrhein C, Varela PF, Damier-Piolle L, Castagne N, MacLellan K, Bedouelle H, Bricogne G, Bhella D, Eleouet JF, Rey FA. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science. 2009 Nov 27;326(5957):1279-83. PMID:19965480 doi:326/5957/1279
• Maclellan K, Loney C, Yeo RP, Bhella D. The 24-angstrom structure of respiratory syncytial virus nucleocapsid protein-RNA decameric rings. J Virol. 2007 Sep;81(17):9519-24. Epub 2007 Jun 13. PMID:17567697 doi:10.1128/JVI.00526-07

1. ↑ Fearns R, Peeples ME, Collins PL. Increased expression of the N protein of respiratory syncytial virus stimulates minigenome replication but does not alter the balance between the synthesis of mRNA and antigenome. Virology. 1997 Sep 15;236(1):188-201. PMID:9299631 doi:10.1006/viro.1997.8734