2wgm

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Template:STRUCTURE 2wgm

Contents 1 Complete ion-coordination structure in the rotor ring of Na-dependent F-ATP synthase 2 Function 3 About this Structure 4 Reference

Complete ion-coordination structure in the rotor ring of Na-dependent F-ATP synthase

Template:ABSTRACT PUBMED 19500592

Function

[ATPL_ILYTA] F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane sodium channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to sodium translocation.[HAMAP-Rule:MF_01396] Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of 11 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.[HAMAP-Rule:MF_01396]

About this Structure

2wgm is a 44 chain structure with sequence from Ilyobacter tartaricus. Full crystallographic information is available from OCA.

Reference

• Meier T, Krah A, Bond PJ, Pogoryelov D, Diederichs K, Faraldo-Gomez JD. Complete ion-coordination structure in the rotor ring of Na+-dependent F-ATP synthases. J Mol Biol. 2009 Aug 14;391(2):498-507. Epub 2009 Jun 3. PMID:19500592 doi:10.1016/j.jmb.2009.05.082