2qmq

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Template:STRUCTURE 2qmq

Contents 1 Crystal structure of a n-myc downstream regulated 2 protein (ndrg2, syld, ndr2, ai182517, au040374) from mus musculus at 1.70 A resolution 2 Function 3 About this Structure 4 Reference

Crystal structure of a n-myc downstream regulated 2 protein (ndrg2, syld, ndr2, ai182517, au040374) from mus musculus at 1.70 A resolution

Template:ABSTRACT PUBMED 21247902

Function

[NDRG2_MOUSE] Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity).

About this Structure

2qmq is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

• Hwang J, Kim Y, Kang HB, Jaroszewski L, Deacon A, Lee H, Choi WC, Kim KJ, Kim CH, Kang BS, Lee JO, Oh TK, Kim JW, Wilson IA, Kim MH. Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor. J Biol Chem. 2011 Jan 18. PMID:21247902 doi:10.1074/jbc.M110.170803