1h22

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 1h22

Contents 1 Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(10)-hupyridone at 2.15A resolution 2 Function 3 About this Structure 4 See Also 5 Reference

Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(10)-hupyridone at 2.15A resolution

Template:ABSTRACT PUBMED 12517147

Function

[ACES_TORCA] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.

About this Structure

1h22 is a 1 chain structure with sequence from Torpedo californica. Full crystallographic information is available from OCA.

See Also

• AChE bivalent inhibitors
• Acetylcholinesterase
• Torpedo Californica Acetylcholinesterase in complex with an (R)-Tacrine-(10)-Hupyridone inhibitor
• User:Dawn M. Wong

Reference

• Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. J Am Chem Soc. 2003 Jan 15;125(2):363-73. PMID:12517147 doi:http://dx.doi.org/10.1021/ja021111w