1sp4

From Proteopedia

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Template:STRUCTURE 1sp4

Contents 1 Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft

Template:ABSTRACT PUBMED 15084146

Function

[CATB_BOVIN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

About this Structure

1sp4 is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

See Also

• Cathepsin

Reference

• Stern I, Schaschke N, Moroder L, Turk D. Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. Biochem J. 2004 Jul 15;381(Pt 2):511-7. PMID:15084146 doi:10.1042/BJ20040237