2whe

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Template:STRUCTURE 2whe

Contents 1 STRUCTURE OF NATIVE BETA-PHOSPHOGLUCOMUTASE IN AN OPEN CONFORMATION WITHOUT BOUND LIGANDS. 2 Function 3 About this Structure 4 Reference

STRUCTURE OF NATIVE BETA-PHOSPHOGLUCOMUTASE IN AN OPEN CONFORMATION WITHOUT BOUND LIGANDS.

Template:ABSTRACT PUBMED 20164409

Function

[PGMB_LACLA] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.^{[1] [2]}

About this Structure

2whe is a 1 chain structure with sequence from Lactococcus lactis. Full crystallographic information is available from OCA.

Reference

• Baxter NJ, Bowler MW, Alizadeh T, Cliff MJ, Hounslow AM, Wu B, Berkowitz DB, Williams NH, Blackburn GM, Waltho JP. Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranes. Proc Natl Acad Sci U S A. 2010 Feb 24. PMID:20164409

1. ↑ Qian N, Stanley GA, Bunte A, Radstrom P. Product formation and phosphoglucomutase activities in Lactococcus lactis: cloning and characterization of a novel phosphoglucomutase gene. Microbiology. 1997 Mar;143 ( Pt 3):855-65. PMID:9084169
2. ↑ Lahiri SD, Zhang G, Dai J, Dunaway-Mariano D, Allen KN. Analysis of the substrate specificity loop of the HAD superfamily cap domain. Biochemistry. 2004 Mar 16;43(10):2812-20. PMID:15005616 doi:10.1021/bi0356810