1y4m

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Template:STRUCTURE 1y4m

Contents

Crystal structure of human endogenous retrovirus HERV-FRD envelope protein (syncitin-2)

Template:ABSTRACT PUBMED 16140326

Function

[EFR1_HUMAN] Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.[1] [2] SU mediates receptor recognition (By similarity).[3] [4] TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).[5] [6]

About this Structure

1y4m is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Renard M, Varela PF, Letzelter C, Duquerroy S, Rey FA, Heidmann T. Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates. J Mol Biol. 2005 Oct 7;352(5):1029-34. PMID:16140326 doi:10.1016/j.jmb.2005.07.058
  1. ↑ Blaise S, de Parseval N, Benit L, Heidmann T. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13013-8. Epub 2003 Oct 13. PMID:14557543 doi:http://dx.doi.org/10.1073/pnas.2132646100
  2. ↑ Blaise S, Ruggieri A, Dewannieux M, Cosset FL, Heidmann T. Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians. J Virol. 2004 Jan;78(2):1050-4. PMID:14694139
  3. ↑ Blaise S, de Parseval N, Benit L, Heidmann T. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13013-8. Epub 2003 Oct 13. PMID:14557543 doi:http://dx.doi.org/10.1073/pnas.2132646100
  4. ↑ Blaise S, Ruggieri A, Dewannieux M, Cosset FL, Heidmann T. Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians. J Virol. 2004 Jan;78(2):1050-4. PMID:14694139
  5. ↑ Blaise S, de Parseval N, Benit L, Heidmann T. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13013-8. Epub 2003 Oct 13. PMID:14557543 doi:http://dx.doi.org/10.1073/pnas.2132646100
  6. ↑ Blaise S, Ruggieri A, Dewannieux M, Cosset FL, Heidmann T. Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians. J Virol. 2004 Jan;78(2):1050-4. PMID:14694139

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