1hqz

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Template:STRUCTURE 1hqz

Contents 1 Cofilin homology domain of a yeast actin-binding protein ABP1P 2 Function 3 About this Structure 4 Reference

Cofilin homology domain of a yeast actin-binding protein ABP1P

Template:ABSTRACT PUBMED 15735338

Function

[ABP1_YEAST] Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis.^[1]

About this Structure

1hqz is a 9 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

• Strokopytov BV, Fedorov A, Mahoney NM, Kessels M, Drubin DG, Almo SC. Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches. Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):285-93. Epub 2005, Feb 24. PMID:15735338 doi:10.1107/S0907444904033037

1. ↑ Goode BL, Rodal AA, Barnes G, Drubin DG. Activation of the Arp2/3 complex by the actin filament binding protein Abp1p. J Cell Biol. 2001 Apr 30;153(3):627-34. PMID:11331312