1iic

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Template:STRUCTURE 1iic

Contents

Crystal Structure of Saccharomyces cerevisiae N-myristoyltransferase with Bound MyristoylCoA

Template:ABSTRACT PUBMED 11371195

Function

[NMT_YEAST] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Uncharged amino acids are preferred at position 2 while neutral residues are favored at positions 3 and 4. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6.

About this Structure

1iic is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Farazi TA, Waksman G, Gordon JI. Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. Biochemistry. 2001 May 29;40(21):6335-43. PMID:11371195

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