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Template:STRUCTURE 1wmg

Contents 1 Crystal structure of the UNC5H2 death domain 2 Function 3 About this Structure 4 Reference

Crystal structure of the UNC5H2 death domain

Template:ABSTRACT PUBMED 17139086

Function

[UNC5B_MOUSE] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).^[1]

About this Structure

1wmg is a 6 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

• Handa N, Kukimoto-Niino M, Akasaka R, Murayama K, Terada T, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Nunokawa E, Tanaka A, Hayashizaki Y, Kigawa T, Shirouzu M, Yokoyama S. Structure of the UNC5H2 death domain. Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1502-9. Epub 2006, Nov 23. PMID:17139086 doi:10.1107/S0907444906039369

1. ↑ Llambi F, Lourenco FC, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, Mehlen P. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J. 2005 Mar 23;24(6):1192-201. Epub 2005 Feb 24. PMID:15729359 doi:http://dx.doi.org/10.1038/sj.emboj.7600584