1dgp

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Template:STRUCTURE 1dgp

Contents

ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX

Template:ABSTRACT PUBMED 10825154

Function

[ARIS_PENRO] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce aristolochene. Aristolochene is the likely parent compound for a number of sesquiterpenoid toxins produced by filamentous fungi.[1] [2]

About this Structure

1dgp is a 2 chain structure with sequence from Penicillium roqueforti. Full crystallographic information is available from OCA.

Reference

  • Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW. Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti. J Biol Chem. 2000 Aug 18;275(33):25533-9. PMID:10825154 doi:10.1074/jbc.M000433200
  1. ↑ Proctor RH, Hohn TM. Aristolochene synthase. Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Ari1) from Penicillium roqueforti. J Biol Chem. 1993 Feb 25;268(6):4543-8. PMID:8440737
  2. ↑ Felicetti B, Cane DE. Aristolochene synthase: mechanistic analysis of active site residues by site-directed mutagenesis. J Am Chem Soc. 2004 Jun 16;126(23):7212-21. PMID:15186158 doi:10.1021/ja0499593

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