1pvj
From Proteopedia
Contents |
Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex
Function
[SPEB_STRPY] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.[1]
About this Structure
1pvj is a 4 chain structure with sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.
