1j89

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Template:STRUCTURE 1j89

Contents

HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), TETRAGONAL CRYSTAL FORM 2

Template:ABSTRACT PUBMED 11531339

Function

[FCERA_HUMAN] Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

About this Structure

1j89 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Garman SC, Sechi S, Kinet JP, Jardetzky TS. The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. J Mol Biol. 2001 Aug 31;311(5):1049-62. PMID:11531339 doi:10.1006/jmbi.2001.4929

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