1u87

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Template:STRUCTURE 1u87

Contents

Crystal Structure Of The 26 Kda Glutathione S-Transferase Y7F mutant From Schistosoma Japonicum Complexed With Glutathione

Template:ABSTRACT PUBMED 15667211

Function

[GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

About this Structure

1u87 is a 1 chain structure with sequence from Schistosoma japonicum. Full crystallographic information is available from OCA.

See Also

Reference

  • Andujar-Sanchez M, Smith AW, Clemente-Jimenez JM, Rodriguez-Vico F, Las Heras-Vazquez FJ, Jara-Perez V, Camara-Artigas A. Crystallographic and thermodynamic analysis of the binding of S-octylglutathione to the Tyr 7 to Phe mutant of glutathione S-transferase from Schistosoma japonicum. Biochemistry. 2005 Feb 1;44(4):1174-83. PMID:15667211 doi:10.1021/bi0483110

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