1s3z

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 1s3z

Contents 1 Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and Ribostamycin 2 Function 3 About this Structure 4 Reference

Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and Ribostamycin

Template:ABSTRACT PUBMED 15123251

Function

[Q9R381_SALEN] Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, dibekacin and ribostamycin. Able to acetylate eukaryotic histone proteins.^{[1] [2]}

About this Structure

1s3z is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar enteritidis. Full crystallographic information is available from OCA.

Reference

• Vetting MW, Magnet S, Nieves E, Roderick SL, Blanchard JS. A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones. Chem Biol. 2004 Apr;11(4):565-73. PMID:15123251 doi:10.1016/j.chembiol.2004.03.017

1. ↑ Magnet S, Courvalin P, Lambert T. Activation of the cryptic aac(6')-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion. J Bacteriol. 1999 Nov;181(21):6650-5. PMID:10542165
2. ↑ Vetting MW, Magnet S, Nieves E, Roderick SL, Blanchard JS. A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones. Chem Biol. 2004 Apr;11(4):565-73. PMID:15123251 doi:10.1016/j.chembiol.2004.03.017