1xw9

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Template:STRUCTURE 1xw9

Contents

Drosophila thioredoxin, oxidized, P21

Template:ABSTRACT PUBMED 15644209

Function

[THIO2_DROME] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1.[1]

About this Structure

1xw9 is a 4 chain structure with sequence from Drome. Full crystallographic information is available from OCA.

See Also

Reference

  • Wahl MC, Irmler A, Hecker B, Schirmer RH, Becker K. Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster. J Mol Biol. 2005 Feb 4;345(5):1119-30. Epub 2004 Dec 16. PMID:15644209 doi:10.1016/j.jmb.2004.11.004
  1. ↑ Bauer H, Kanzok SM, Schirmer RH. Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2. J Biol Chem. 2002 May 17;277(20):17457-63. Epub 2002 Mar 4. PMID:11877442 doi:http://dx.doi.org/10.1074/jbc.M200636200

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