2fci

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Template:STRUCTURE 2fci

Contents

Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase

Template:ABSTRACT PUBMED 16410013

Function

[PLCG1_BOVIN] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).

About this Structure

2fci is a 2 chain structure with sequence from Bos taurus. Full experimental information is available from OCA.

Reference

  • Groesch TD, Zhou F, Mattila S, Geahlen RL, Post CB. Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase. J Mol Biol. 2006 Mar 10;356(5):1222-36. Epub 2005 Dec 27. PMID:16410013 doi:10.1016/j.jmb.2005.11.095

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