2i99

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Template:STRUCTURE 2i99

Contents

Crystal structure of human Mu_crystallin at 2.6 Angstrom

Template:ABSTRACT PUBMED 17242435

Function

[CRYM_HUMAN] Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.[1]

About this Structure

2i99 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Cheng Z, Sun L, He J, Gong W. Crystal structure of human micro-crystallin complexed with NADPH. Protein Sci. 2007 Feb;16(2):329-35. PMID:17242435 doi:http://dx.doi.org/16/2/329
  1. ↑ Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD. Mammalian forebrain ketimine reductase identified as mu-crystallin; potential regulation by thyroid hormones. J Neurochem. 2011 Aug;118(3):379-87. doi: 10.1111/j.1471-4159.2011.07220.x. Epub , 2011 Mar 15. PMID:21332720 doi:http://dx.doi.org/10.1111/j.1471-4159.2011.07220.x

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