1nw3

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Template:STRUCTURE 1nw3

Contents 1 Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase 2 Function 3 About this Structure 4 See Also 5 Reference

Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

Template:ABSTRACT PUBMED 12628190

Function

[DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

About this Structure

1nw3 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

• Histone methyltransferase

Reference

• Min J, Feng Q, Li Z, Zhang Y, Xu RM. Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. Cell. 2003 Mar 7;112(5):711-23. PMID:12628190